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Melanotan II (MT2)

$45.00

Melanotan II (MT2) — a synthetic cyclic α-MSH analog and superpotent, non-selective melanocortin-receptor agonist used as a reference compound in pigmentation and melanocortin-pharmacology research. For laboratory research use only.

View this lot’s Certificate of Analysis (HPLC + MS) →Independently tested by Freedom Diagnostics (U.S.A.)

≥99% purity — tested per lot by Freedom Diagnostics
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Research use only
Supplied strictly for in-vitro laboratory research and development. Not for human or veterinary use. Not a drug, supplement, food, or cosmetic.

Description

Melanotan II (MT2) is a synthetic, cyclic analog of alpha-melanocyte-stimulating hormone (α-MSH). A lactam bridge between its aspartate and lysine side chains locks the peptide into a rigid ring, making it a superpotent, long-acting melanocortin-receptor agonist and a widely used reference compound in pigmentation and melanocortin-pharmacology research.

Melanotan II Specifications

  • Classification: Synthetic cyclic lactam heptapeptide; non-selective melanocortin-receptor (MC1R–MC5R) agonist
  • Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (Nle⁴, D-Phe⁷, Asp–Lys lactam bridge)
  • Molecular formula: C50H69N15O9
  • Molecular weight: ~1024.2 g/mol (free base)
  • CAS number: 121062-08-6
  • Appearance: White to off-white lyophilized powder
  • Solubility: Soluble in water and bacteriostatic water for reconstitution in the laboratory
  • Storage: Store lyophilized at -20 °C, protected from light and moisture; avoid repeated freeze-thaw cycles

Research focus

Melanotan II is studied in melanocortin-receptor pharmacology (MC1R/MC3R/MC4R/MC5R binding and selectivity), pigmentation and melanogenesis models, energy-balance and feeding-behavior research via MC4R signaling, and melanocortin-pathway anti-inflammatory signaling. It also serves as the parent scaffold for the more receptor-selective analog PT-141 (bremelanotide).

Good to know

  • The Nle⁴ substitution resists oxidation and D-Phe⁷ resists proteolysis, while the Asp–Lys lactam ring locks the pharmacophore — together giving MT2 far greater stability and potency than linear α-MSH.
  • As a non-selective agonist it activates all four melanocortin receptor subtypes, which is why it is a common reference ligand in receptor-selectivity studies.
  • Commonly supplied as the acetate salt; the salt form raises the practical molecular weight above the free-base value.

For laboratory research use only. Not for human or veterinary use.

Certificate of Analysis

Lot MT411
Purity (HPLC)99.27%
Identity (MS)Confirmed
EndotoxinPass (≤0.05 EU/mL)
Tested12 Aug 2026

This certificate is served directly from the laboratory’s own domain coas.freedomdiagnosticstesting.com — not from our server.

Search codeInte2608070315
Verify this result at the lab →

Paste the search code into Freedom Diagnostics’ own lookup to confirm these results at the source.

Net content9.40 mg
AppearanceWhite Lyophilized Powder
Microbial (PCR)No Detectable Microbial DNA

Testing is carried out independently by Freedom Diagnostics, a U.S. analytical laboratory. Every certificate is published in full — never behind a request form.

Common questions

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How quickly will my order ship?

Orders are dispatched within 1–2 business days in plain, unbranded packaging. Every parcel is tracked and the tracking number lands in your inbox. Shipping is free on orders over $150.

How do I verify this lot’s Certificate of Analysis?

Every lot is tested by HPLC and mass spec at Freedom Diagnostics (U.S.A.) and the certificate is published — never hidden behind a request form. Open the COA link above the price, or browse all certificates on our Certificates page, where we also explain how to verify a report with the lab directly.

How should vials be stored on arrival?

Keep lyophilized vials sealed in a cool, dry place away from light; refrigeration or freezing is standard laboratory practice for long-term storage. Handle all materials per good laboratory practice.

What if my order arrives wrong or damaged?

Email us with your order number and a photo — we replace the item or credit your wallet. Full details are on the Shipping & Returns page.

Who can purchase from Integratide?

Qualified researchers and institutions only. Everything we sell is strictly for in-vitro laboratory research — not for human or veterinary use of any kind — and checkout requires a 21+ research-use attestation.

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