Description
Tesamorelin is a synthetic analog of human growth-hormone-releasing hormone (GHRH) — the full 44-amino-acid hormone sequence with a stabilizing chemical modification that makes it more potent and longer-lived than the native peptide. As a well-characterized growth-hormone secretagogue, it is a valuable reference compound in endocrinology and metabolic research on the GH/IGF-1 axis.
Tesamorelin Specifications
- Classification: Synthetic GHRH (GRF 1-44) analog; growth-hormone secretagogue
- Sequence: N-(trans-3-hexenoyl)-[Tyr1]-hGRF(1-44) amide (the full 44-residue human GHRH sequence, N-terminally modified)
- Molecular formula: C221H366N72O67S
- Molecular weight: ~5135.9 g/mol
- CAS number: 218949-48-5
- Appearance: White to off-white lyophilized powder
- Solubility: Soluble in aqueous solution to a clear, colorless solution
- Storage: Store lyophilized at -20 °C, sealed and desiccated
Research focus
Tesamorelin is studied across the growth-hormone / IGF-1 secretagogue axis, visceral adipose tissue and body-composition models, lipid metabolism and lipolysis, hepatic-fat metabolic models, and peptide stability and pharmacokinetics.
Good to know
- Built on the complete 44-amino-acid sequence of endogenous human GHRH, distinguished by a trans-3-hexenoyl group on the N-terminal tyrosine that increases potency and resistance to enzymatic degradation.
- Acts as a secretagogue — in research models it engages pituitary GHRH receptors to stimulate the body’s own GH/IGF-1 pathways rather than introducing external growth hormone.
- Originally developed by Theratechnologies and extensively referenced in the scientific literature on the GH/IGF-1 axis and visceral adipose tissue.
For laboratory reconstitution, pair with our bacteriostatic water.







