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Retatrutide

$95.00

A first-in-class synthetic “triple agonist” that engages the GIP, GLP-1, and glucagon receptors — a leading reference compound in metabolic and incretin-pharmacology research.

View this lot’s Certificate of Analysis (HPLC + MS) →Independently tested by Freedom Diagnostics (U.S.A.)

≥99% purity — tested per lot by Freedom Diagnostics
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Research use only
Supplied strictly for in-vitro laboratory research and development. Not for human or veterinary use. Not a drug, supplement, food, or cosmetic.

Description

Retatrutide is a cutting-edge synthetic peptide and the first of a new class of “triple agonists” — a single molecule engineered to engage three metabolic receptors at once: GIP, GLP-1, and glucagon. Developed as Eli Lilly’s LY3437943, it is among the most studied compounds in modern metabolic research and a valuable reference standard for incretin-receptor pharmacology.

Retatrutide Specifications

  • Classification: Synthetic GIP / GLP-1 / glucagon (triple incretin) receptor agonist
  • Sequence: 39-residue synthetic peptide on a GIP-based backbone with non-coded residues (two Aib, an alpha-methyl-leucine) and a C20 fatty-diacid / AEEA-gamma-Glu albumin-binding side chain
  • Molecular formula: C221H342N46O68
  • Molecular weight: ~4731.3 g/mol
  • CAS number: 2381089-83-2
  • Appearance: White to off-white lyophilized powder
  • Solubility: Soluble in water and aqueous buffers (e.g., PBS, pH ~7.2)
  • Storage: Store lyophilized frozen (at or below -20 °C), protected from light and moisture; avoid freeze-thaw cycles

Research focus

Retatrutide is studied across energy-homeostasis and body-weight regulation models, glucose regulation, incretin-receptor pharmacology (GLP-1R / GIPR / GCGR signaling), metabolic liver-disease (MASLD) models, and the structural biology of class-B GPCR-peptide complexes.

Good to know

  • A first-in-class triple agonist: one peptide that simultaneously activates the GIP, GLP-1, and glucagon receptors.
  • Built on a GIP-based backbone with non-natural amino acids (Aib and alpha-methyl-leucine) and a C20 fatty-diacid chain that binds albumin to extend its half-life.
  • Cryo-EM structural studies have resolved how a single molecule binds and activates all three receptors — a milestone in incretin pharmacology.

For laboratory reconstitution, pair with our bacteriostatic water.

Certificate of Analysis

Lot RT312
Purity (HPLC)99.77%
Identity (MS)Confirmed
EndotoxinPass (≤0.05 EU/mL)
Tested12 Aug 2026

This certificate is served directly from the laboratory’s own domain coas.freedomdiagnosticstesting.com — not from our server.

Search codeInte2608070312
Verify this result at the lab →

Paste the search code into Freedom Diagnostics’ own lookup to confirm these results at the source.

Net content11.86 mg
AppearanceWhite Lyophilized Powder
Microbial (PCR)No Detectable Microbial DNA

Testing is carried out independently by Freedom Diagnostics, a U.S. analytical laboratory. Every certificate is published in full — never behind a request form.

Common questions

How do payments work?

We accept credit and debit cards (you’re securely redirected to complete payment), plus Cash App, Venmo, Zelle, and crypto. Pick your method at checkout and follow the on-screen steps — card payments confirm instantly; app and crypto payments we confirm fast, usually within the hour, and your order moves straight to packing.

How quickly will my order ship?

Orders are dispatched within 1–2 business days in plain, unbranded packaging. Every parcel is tracked and the tracking number lands in your inbox. Shipping is free on orders over $150.

How do I verify this lot’s Certificate of Analysis?

Every lot is tested by HPLC and mass spec at Freedom Diagnostics (U.S.A.) and the certificate is published — never hidden behind a request form. Open the COA link above the price, or browse all certificates on our Certificates page, where we also explain how to verify a report with the lab directly.

How should vials be stored on arrival?

Keep lyophilized vials sealed in a cool, dry place away from light; refrigeration or freezing is standard laboratory practice for long-term storage. Handle all materials per good laboratory practice.

What if my order arrives wrong or damaged?

Email us with your order number and a photo — we replace the item or credit your wallet. Full details are on the Shipping & Returns page.

Who can purchase from Integratide?

Qualified researchers and institutions only. Everything we sell is strictly for in-vitro laboratory research — not for human or veterinary use of any kind — and checkout requires a 21+ research-use attestation.

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